Delivery methods for RNA interference in C. elegans

Methods Mol Biol. 2006;351:119-25. doi: 10.1385/1-59745-151-7:119.


This chapter describes four methods for delivery of double-stranded RNA to Caenorhabditis elegans (injection, feeding, soaking, and in vivo delivery), and suggests schemes that should facilitate detection of specific gene silencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Gene Transfer Techniques*
  • Genes, Helminth / genetics*
  • RNA Interference
  • RNA, Double-Stranded / genetics*
  • RNA, Double-Stranded / pharmacology


  • RNA, Double-Stranded