Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance

Eur J Clin Nutr. 2007 Mar;61(3):334-41. doi: 10.1038/sj.ejcn.1602525. Epub 2006 Sep 20.


Objective: Arabinoxylan (AX) consumption is associated with metabolic improvement during diabetes and with modulation of ghrelin, an orexigenic gut hormone. The effect of AX consumption on ghrelin secretion in disturbed metabolic states is unknown. Therefore, we investigated the postprandial responses to AX consumption of serum glucose, insulin and triglycerides and plasma total and acylated ghrelin in subjects with impaired glucose tolerance (IGT).

Design: Randomized, single-blind, controlled, crossover intervention trial.

Subjects: Seven female and four male adults with IGT, aged 55.5 years, and body mass index (BMI) 30.1 kg/m(2).

Intervention: Subjects received either placebo or 15 g AX supplement for 6 weeks with a 6-week washout period in-between.

Main outcome measurements: Postprandial responses of serum glucose, insulin and triglycerides, and plasma total and acylated ghrelin after a liquid meal challenge test (LMCT) measured at the beginning and at the end of the dietary intervention at -20, -5, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 min.

Results: After LMCT, AX consumption resulted in lower postprandial responses in serum glucose, insulin and triglycerides (P<0.05). Compared to placebo, total plasma ghrelin was also reduced by 42+/-8 pg/ml (P<0.001) after AX consumption with no difference in plasma acylated ghrelin.

Conclusion: AX consumption improved postprandial metabolic responses after an LMCT in subjects with IGT and reduced total ghrelin response. However, acylated ghrelin responses were unchanged, suggesting that the acylated ghrelin-mediated orexigenic regulation is not improved as only total plasma ghrelin decreased.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Area Under Curve
  • Blood Glucose / metabolism*
  • Cross-Over Studies
  • Dietary Fiber / administration & dosage*
  • Dietary Supplements
  • Female
  • Ghrelin
  • Glucose Intolerance / blood
  • Glucose Intolerance / drug therapy*
  • Glucose Intolerance / metabolism
  • Humans
  • Insulin / blood*
  • Male
  • Middle Aged
  • Peptide Hormones / blood*
  • Postprandial Period
  • Single-Blind Method
  • Solubility
  • Time Factors
  • Triglycerides / blood
  • Xylans / administration & dosage*


  • Blood Glucose
  • Dietary Fiber
  • Ghrelin
  • Insulin
  • Peptide Hormones
  • Triglycerides
  • Xylans
  • arabinoxylan