Systemic lupus erythematosus and the brain: what mice are telling us

Neurochem Int. 2007 Jan;50(1):5-11. doi: 10.1016/j.neuint.2006.08.005. Epub 2006 Sep 20.


Neuropsychiatric symptoms occur in systemic lupus erythematosus (SLE), a complex, autoimmune disease of unknown origin. Although several pathogenic mechanisms have been suggested to play a significant role in the etiology of the disease, the exact underlying mechanisms still remain elusive. Several inbred strains of mice are used as models to study SLE, which exhibit a diversity of central nervous system (CNS) manifestations similar to that observed in patients. This review will attempt to give a brief overview of the CNS alterations observed in these models, including biochemical, structural and behavioral changes.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Animal*
  • Brain / physiopathology*
  • Disease Models, Animal*
  • Lupus Erythematosus, Systemic / physiopathology*
  • Mice