The mTOR pathway in the control of protein synthesis

Physiology (Bethesda). 2006 Oct;21:362-9. doi: 10.1152/physiol.00024.2006.

Abstract

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena
  • Humans
  • Protein Biosynthesis*
  • Protein Kinases / metabolism
  • Protein Kinases / physiology*
  • Ribosomes
  • Signal Transduction
  • TOR Serine-Threonine Kinases

Substances

  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases