The ARP2/3 complex: an actin nucleator comes of age

Nat Rev Mol Cell Biol. 2006 Oct;7(10):713-26. doi: 10.1038/nrm2026.


The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Actin-Related Protein 2-3 Complex / chemistry
  • Actin-Related Protein 2-3 Complex / genetics
  • Actin-Related Protein 2-3 Complex / metabolism*
  • Actins / genetics
  • Actins / metabolism*
  • Animals
  • Humans
  • In Vitro Techniques
  • Models, Biological


  • Actin-Related Protein 2-3 Complex
  • Actins

Associated data

  • PDB/1A8K
  • PDB/1ATN