Rapamycin Biosynthesis: Elucidation of Gene Product Function

Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22.

Abstract

The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genes*
  • Genetic Complementation Test
  • Mass Spectrometry
  • Sirolimus / analogs & derivatives
  • Sirolimus / chemistry
  • Sirolimus / metabolism*

Substances

  • Sirolimus