Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses

Biochim Biophys Acta. 2006 Oct;1763(10):991-9. doi: 10.1016/j.bbamcr.2006.08.008. Epub 2006 Aug 18.


Thy-1 is a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell activation, neurite outgrowth, apoptosis, tumor suppression, wound healing, and fibrosis. To mediate these diverse effects, Thy-1 participates in multiple signaling cascades. In this review, we discuss Thy-1 signaling primarily in non-immunologic cell types, including neurons, mesangial cells, ovarian cancer cells, nasopharyngeal carcinoma cells, endothelial cells, and fibroblasts. We review the current literature regarding Thy-1 signaling via integrins, protein tyrosine kinases, and cytokines and growth factors; and the roles of these signaling pathways in cellular adhesion, apoptosis, cell proliferation, and cell adhesion and migration. We also discuss the role of Thy-1 localization to lipid rafts, and of the GPI anchor in Thy-1 signaling. Ongoing research on the mechanisms of Thy-1 signaling will add to our understanding of the diverse physiologic and pathologic processes in which Thy-1 plays a role.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Adhesion
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Cytokines / metabolism*
  • Cytokines / physiology
  • Integrins / metabolism
  • Integrins / physiology
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Intercellular Signaling Peptides and Proteins / physiology
  • Membrane Microdomains / metabolism
  • Mice
  • Models, Biological
  • Protein-Tyrosine Kinases / metabolism
  • Protein-Tyrosine Kinases / physiology
  • Signal Transduction*
  • Thy-1 Antigens / genetics
  • Thy-1 Antigens / metabolism*
  • Thy-1 Antigens / physiology*


  • Cytokines
  • Integrins
  • Intercellular Signaling Peptides and Proteins
  • Thy-1 Antigens
  • Protein-Tyrosine Kinases