In vitro evaluation of the pollen extract, cernitin T-60, in the regulation of prostate cell growth

Br J Urol. 1990 Oct;66(4):393-7. doi: 10.1111/j.1464-410x.1990.tb14961.x.


Nine human-derived cancer and non-cancer continuous cell lines were employed to evaluate the relative in vitro activity of the pollen extract, Cernitin T-60. Responses of the cell lines to the drug were assessed by measuring growth and cell survival as determined by cell count. The results demonstrated that of the 9 continuous cell lines tested, only those derived from the human prostate were growth inhibited by the pollen extract, whereas the non-prostate derived cells exhibited variable degrees of resistance to the T-60. The selectivity of the drug for the prostate cell lines was even more pronounced in the hormone-independent models, suggesting that there might be a place for the pollen extract in the control of abnormal growth in hormone-insensitive cells.

Publication types

  • Comparative Study

MeSH terms

  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism
  • Cell Count
  • Cell Division / drug effects
  • Cell Line
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Plant Extracts*
  • Pollen*
  • Prostate / cytology
  • Prostate / drug effects*
  • Prostatic Hyperplasia / metabolism
  • Prostatic Neoplasms / drug therapy
  • Secale
  • Tumor Cells, Cultured / drug effects


  • Plant Extracts
  • cernilton
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase