The import receptor Pex7p and the PTS2 targeting sequence

Biochim Biophys Acta. 2006 Dec;1763(12):1599-604. doi: 10.1016/j.bbamcr.2006.08.011. Epub 2006 Aug 22.

Abstract

This chapter concerns one branch of the peroxisome import pathway for newly-synthesized peroxisomal proteins, specifically the branch for matrix proteins that contain a peroxisome targeting sequence type 2 (PTS2). The structure and utilization of the PTS2 are discussed, as well as the properties of the receptor, Pex7p, which recognizes the PTS2 sequence and conveys these proteins to the common translocation machinery in the peroxisome membrane. We also describe the recent evidence that this receptor recycles into the peroxisome matrix and back out to the cytosol in the course of its function. Pex7p is assisted in its functioning by several species-specific auxiliary proteins that are described in the following chapter.

Publication types

  • Review

MeSH terms

  • Animals
  • Chondrodysplasia Punctata, Rhizomelic / genetics
  • Chondrodysplasia Punctata, Rhizomelic / metabolism
  • Humans
  • Mutation
  • Peroxisomal Targeting Signal 2 Receptor
  • Peroxisomes / physiology*
  • Protein Sorting Signals*
  • Protein Transport
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Refsum Disease / genetics
  • Refsum Disease / metabolism

Substances

  • Peroxisomal Targeting Signal 2 Receptor
  • Protein Sorting Signals
  • Receptors, Cytoplasmic and Nuclear