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, 25 (43), 5825-31

Clinical Management of BRCA1 and BRCA2 Mutation Carriers


Clinical Management of BRCA1 and BRCA2 Mutation Carriers

S M Domchek et al. Oncogene.


The cancer susceptibility genes BRCA1 and BRCA2 appear to be responsible for virtually all hereditary breast ovarian families, and a smaller subset of hereditary site-specific breast cancer families. Fortunately, effective strategies have been developed to reduce the risk for the development of breast and ovarian cancer in women with BRCA1/2 mutations, making genetic testing for these mutations an important part of the management at women with a strong family history of these diseases. Here, we review the current evidence for risk reduction strategies and outline future research directions.

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