Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 6 (10), 728-40

Receptor Editing in Lymphocyte Development and Central Tolerance


Receptor Editing in Lymphocyte Development and Central Tolerance

David Nemazee. Nat Rev Immunol.


The specificities of lymphocytes for antigen are generated by a quasi-random process of gene rearrangement that often results in non-functional or autoreactive antigen receptors. Regulation of lymphocyte specificities involves not only the elimination of cells that display 'unsuitable' receptors for antigen but also the active genetic correction of these receptors by secondary recombination of the DNA. As I discuss here, an important mechanism for the genetic correction of antigen receptors is ongoing recombination, which leads to receptor editing. Receptor editing is probably an adaptation that is necessitated by the high probability of receptor autoreactivity. In both B cells and T cells, the genes that encode the two chains of the antigen receptor seem to be specialized to promote, on the one hand, the generation of diverse specificities and, on the other hand, the regulation of these specificities through efficient editing.

Similar articles

  • B Cell Receptor Editing in Tolerance and Autoimmunity
    ET Luning Prak et al. Ann N Y Acad Sci 1217, 96-121. PMID 21251012. - Review
    Receptor editing is the process of ongoing antibody gene rearrangement in a lymphocyte that already has a functional antigen receptor. The expression of a functional anti …
  • Lymphocytes Rearrange, Edit and Revise Their Antigen Receptors to Be Useful Yet Safe
    PJ Fink et al. Immunol Today 21 (11), 561-6. PMID 11094260. - Review
    Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special attention paid to T-cell …
  • The Scope of Receptor Editing and Its Association With Autoimmunity
    LK Verkoczy et al. Curr Opin Immunol 16 (6), 808-14. PMID 15511677. - Review
    Random assembly of antibody variable (V), diversity (D) and joining (J) gene segments creates a vast repertoire of antigen receptors, including autoreactive ones. Three w …
  • Receptor Editing in Developing T Cells
    MA McGargill et al. Nat Immunol 1 (4), 336-41. PMID 11017106.
    A central tenet of T cell development postulates that if a developing thymocyte encounters self-antigen, it is induced to die via apoptosis, thereby protecting the organi …
  • Immune Receptor Editing: Revise and Select
    MC Nussenzweig. Cell 95 (7), 875-8. PMID 9875841. - Review
    Secondary antigen receptor gene recombination occurs in developing lymphocytes, and in more mature T and B cells. In the developing lymphocyte, "editing" occurs in respon …
See all similar articles

Cited by 131 PubMed Central articles

See all "Cited by" articles

Publication types


LinkOut - more resources