PTP1B and TC-PTP: novel roles in immune-cell signaling

Paul D Simoncic; C Jane McGlade; Michel L Tremblay

doi:10.1139/y06-012

PTP1B and TC-PTP: novel roles in immune-cell signaling

Can J Physiol Pharmacol. 2006 Jul;84(7):667-75. doi: 10.1139/y06-012.

Authors

Paul D Simoncic¹, C Jane McGlade, Michel L Tremblay

Affiliation

¹ The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

PMID: 16998530
DOI: 10.1139/y06-012

Abstract

It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate specificities of PTP1B and TC-PTP and their roles in immune cell signaling, and will discuss some new data implicating PTP1B and TC-PTP in myeloid development.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Leukocytes / immunology*
Leukocytes / metabolism
Models, Immunological
Protein Tyrosine Phosphatase, Non-Receptor Type 2
Protein Tyrosine Phosphatases / metabolism*
Protein Tyrosine Phosphatases / physiology
Signal Transduction / immunology*
Substrate Specificity

Substances

PTPN2 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 2
Protein Tyrosine Phosphatases