[Lysis therapy vs. conservative therapy: randomised and prospective study on the treatment of acute central retinal artery occlusion (EAGLE study)]

Ophthalmologe. 2006 Oct;103(10):898-900. doi: 10.1007/s00347-006-1429-1.
[Article in German]


In the prospective, randomised and multicenter EAGLE study, the therapeutic efficiency of local intra-arterial fibrinolysis (LIF) versus conservative treatment is being tested in patients with an acute central retinal artery occlusion (CRAO). The most important inclusion criteria are: (1) age between 18-75 years, (2) CRAO not older than 20 h, and (3) visual acuity <0.32. The primary study endpoint is the visual acuity before and 1 month after therapy. The study was started in 2002. To August 2006, 63 of the 200 required patients have been included in the study at 17 medical centers in Germany, Switzerland and Austria.

Publication types

  • English Abstract
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Europe
  • Humans
  • Multicenter Studies as Topic*
  • Prospective Studies
  • Randomized Controlled Trials as Topic*
  • Retinal Artery Occlusion / complications
  • Retinal Artery Occlusion / therapy*
  • Thrombolytic Therapy / methods*
  • Treatment Outcome
  • Vision Disorders / diagnosis
  • Vision Disorders / etiology
  • Vision Disorders / prevention & control*