[Effect of the concomitant administration of indomethacin or ibuprofen on amikacin pharmacokinetics in premature newborns]

Farm Hosp. 2006 May-Jun;30(3):149-53. doi: 10.1016/s1130-6343(06)73965-4.
[Article in Spanish]

Abstract

Objective: To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug s pharmacokinetic parameters, and hence amikacin plasma levels.

Method: Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearance were measured using the PKS program (a non-linear regression method). Half life was determined from previous parameters.

Results: Twenty-eight patients were included. No statistically significant differences were found among pharmacokinetic parameters corresponding to each study group.

Conclusions: Further studies are needed with a greater number of patients and currently recommended doses to assess the influence of indomethacin and ibuprofen in the pharmacokinetics of amikacin in premature children with persistent ductus arteriosus.

Publication types

  • English Abstract

MeSH terms

  • Amikacin / pharmacokinetics*
  • Anti-Bacterial Agents / pharmacokinetics*
  • Cohort Studies
  • Cyclooxygenase Inhibitors / administration & dosage
  • Cyclooxygenase Inhibitors / pharmacology*
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Humans
  • Ibuprofen / administration & dosage
  • Ibuprofen / pharmacology*
  • Indomethacin / administration & dosage
  • Indomethacin / pharmacology*
  • Infant, Newborn
  • Infant, Premature*
  • Male
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents
  • Cyclooxygenase Inhibitors
  • Amikacin
  • Ibuprofen
  • Indomethacin