Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

Behav Brain Res. 2006 Dec 15;175(2):415-9. doi: 10.1016/j.bbr.2006.08.034. Epub 2006 Sep 26.


This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Brain / metabolism*
  • Dietary Fats
  • Dopamine Plasma Membrane Transport Proteins / metabolism*
  • Energy Metabolism / physiology
  • Hypothalamus / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neostriatum / metabolism
  • Nucleus Accumbens / metabolism
  • Obesity / metabolism*
  • Random Allocation
  • Receptors, Dopamine D2 / metabolism*
  • Statistics, Nonparametric


  • Dietary Fats
  • Dopamine Plasma Membrane Transport Proteins
  • Receptors, Dopamine D2