Fragile X syndrome and autism at the intersection of genetic and neural networks

Nat Neurosci. 2006 Oct;9(10):1221-5. doi: 10.1038/nn1765.


Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioral overlap between autism and FXS suggests some overlapping mechanisms. Understanding how the single-gene alteration in FXS plays out within complex genetic and neural network processes may suggest targets for autism research and illustrate strategies for relating autism to more singular genetic syndromes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autistic Disorder / genetics*
  • Autistic Disorder / pathology*
  • Fragile X Syndrome / genetics*
  • Fragile X Syndrome / pathology*
  • Genetics
  • Humans
  • Models, Biological
  • Nerve Net / pathology*
  • Nerve Net / physiopathology*