Regulation of Receptor Tyrosine Kinase Signaling by GRKs and Beta-Arrestins

Annu Rev Physiol. 2007;69:561-77. doi: 10.1146/annurev.physiol.69.022405.154626.


Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase activity. However, RTKs share many signaling molecules with another unique family of cell surface receptors, the seven-transmembrane receptors (7TMRs), and these receptor families can activate similar signaling cascades. In this review of RTK signaling, we describe the role of cross talk between RTKs and 7TMRs, focusing specifically on the role played in this process by beta-arrestins and by G proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrestins / physiology*
  • Humans
  • Protein-Serine-Threonine Kinases / physiology*
  • Receptor Cross-Talk / physiology
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Signal Transduction / physiology*
  • beta-Arrestins


  • Arrestins
  • beta-Arrestins
  • Receptor Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases