Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece

Clin Microbiol Infect. 2006 Nov;12(11):1138-41. doi: 10.1111/j.1469-0691.2006.01537.x.


Twelve non-repetitive Acinetobacter baumannii isolates producing the carbapenem-hydrolysing oxacillinase OXA-58 were recovered from patients in the same paediatric hospital in Athens, Greece, between November 2003 and May 2005. All isolates were clonally related, but the bla(OXA-58) gene was not always plasmid-located and there were variations in the DNA sequences surrounding the OXA-58 gene in different isolates. This study emphasises the importance of the bla(OXA-58) carbapenemase gene in conferring carbapenem resistance among A. baumannii isolates in Greece.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / isolation & purification
  • Carbapenems / pharmacology*
  • Child
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Disease Outbreaks*
  • Drug Resistance / genetics*
  • Greece / epidemiology
  • Hospitals, Pediatric
  • Hospitals, Urban
  • Humans
  • Risk Factors
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*


  • Carbapenems
  • beta-Lactamases