Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA study

J Thromb Haemost. 2006 Dec;4(12):2629-35. doi: 10.1111/j.1538-7836.2006.02237.x. Epub 2006 Sep 26.

Abstract

Background: Hemostatic factors and endothelial markers may play some role in racial/ethnic differences in cardiovascular disease (CVD) rates. However, little information exists on hemostatic factors and endothelial markers across racial/ethnic groups.

Objectives: To describe, in four American racial/ethnic groups (Caucasian, Black, Hispanic, and Chinese), mean levels of selected hemostatic factors and endothelial markers.

Patients and methods: Multi-ethnic Study of Atherosclerosis baseline data were used (participant age: 45-84 years). Sex-specific analysis of covariance models, and t-tests for pairwise comparisons, were used to compare means of factors and markers. Adjustments were made for demographics and traditional CVD risk factors. Differences were significant at P < 0.05.

Results: Blacks had the highest levels of factor VIII, D-Dimer, plasmin-antiplasmin (PAP), and von Willebrand factor, among the highest levels of fibrinogen and E-selectin (women only), but among the lowest levels of intercellular adhesion molecule 1 (ICAM-1), and, in men, the lowest levels of plasminogen activator inhibitor-1 (PAI-1). Whites and Hispanics tended to have intermediate levels of factors and markers, although they had the highest levels of ICAM-1, and Hispanics had the highest mean levels of fibrinogen and E-selectin (women only). Chinese participants had among the highest levels of PAI-1, but the lowest, or among the lowest, of all other factors and markers. No soluble thrombomodulin differences were observed.

Conclusions: In this large cohort, hemostatic factor and endothelial marker mean levels varied by race/ethnicity, even after adjustment for traditional CVD risk factors.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • African Continental Ancestry Group
  • Aged
  • Aged, 80 and over
  • Asian Americans
  • Biomarkers / blood*
  • Blood Coagulation Factors / metabolism*
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / ethnology*
  • Cardiovascular Diseases / etiology
  • Continental Population Groups*
  • Cross-Sectional Studies
  • Endothelial Cells / metabolism*
  • European Continental Ancestry Group
  • Female
  • Hispanic Americans
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Reference Values
  • Risk Factors
  • Sex Distribution
  • Sex Factors

Substances

  • Biomarkers
  • Blood Coagulation Factors