Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

Yuji Komizu; Yoko Matsumoto; Ryuichi Ueoka

doi:10.1016/j.bmcl.2006.08.099

Membrane targeted chemotherapy with hybrid liposomes for colon tumor cells leading to apoptosis

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6131-4. doi: 10.1016/j.bmcl.2006.08.099. Epub 2006 Sep 26.

Authors

Yuji Komizu¹, Yoko Matsumoto, Ryuichi Ueoka

Affiliation

¹ Graduate Course of Applied Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.

PMID: 17005395
DOI: 10.1016/j.bmcl.2006.08.099

Abstract

A good correlation between 50% inhibitory concentration of hybrid liposomes (HL) composed of 90 mol% dimyristoylphosphatidylcholine and 10 mol% polyoxyethylene(n)dodecyl ether on the growth of human colon tumor (WiDr) cells, and membrane fluidity of HL was obtained. HL distinguished between WiDr and normal colon cells and then fused and accumulated into the membranes of WiDr cells leading to apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis*
Cell Line, Tumor
Cell Membrane*
Colonic Neoplasms / pathology*
Humans
Liposomes
Molecular Structure

Substances

Liposomes