Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus

J Med Microbiol. 2006 Oct;55(Pt 10):1457-1459. doi: 10.1099/jmm.0.46639-0.

Abstract

The case is reported of a patient with cavitary sarcoidosis complicated by an aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus, who was treated with voriconazole. The authors suggest that susceptibility testing of A. fumigatus strains is of value during long-term therapy with itraconazole, and that voriconazole may be a good option for treatment of patients infected with itraconazole-resistant strains of A. fumigatus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / pharmacology*
  • Aspergillosis / drug therapy*
  • Aspergillosis / etiology
  • Aspergillosis / microbiology
  • Aspergillus fumigatus / drug effects*
  • Drug Resistance, Fungal
  • Humans
  • Hydroxycorticosteroids / therapeutic use
  • Itraconazole / pharmacology*
  • Lung Diseases, Fungal / drug therapy*
  • Lung Diseases, Fungal / etiology
  • Lung Diseases, Fungal / microbiology
  • Male
  • Microbial Sensitivity Tests
  • Pyrimidines / therapeutic use*
  • Sarcoidosis / complications
  • Sarcoidosis / drug therapy
  • Treatment Outcome
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Hydroxycorticosteroids
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Voriconazole