Linking data to models: data regression

Nat Rev Mol Cell Biol. 2006 Nov;7(11):813-9. doi: 10.1038/nrm2030. Epub 2006 Sep 27.


Mathematical models are an essential tool in systems biology, linking the behaviour of a system to the interactions between its components. Parameters in empirical mathematical models must be determined using experimental data, a process called regression. Because experimental data are noisy and incomplete, diagnostics that test the structural identifiability and validity of models and the significance and determinability of their parameters are needed to ensure that the proposed models are supported by the available data.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Computer Simulation*
  • Humans
  • Microtubules / metabolism*
  • Models, Biological*
  • Plant Physiological Phenomena
  • Regression Analysis*
  • Stochastic Processes
  • Systems Biology*
  • Systems Theory*