Pro-angiogenic cytokines and their role in tumor angiogenesis

Cancer Metastasis Rev. 2006 Sep;25(3):373-85. doi: 10.1007/s10555-006-9011-5.


The development of solid tumors depends upon an adequate supply of blood. This can be achieved by way of co-option of preexisting blood vessels and by the induction of angiogenesis. During the past 30 years, tumor angiogenesis had been found to play a crucial role in the progression of solid tumors. Tumor angiogenesis was found to be induced by a variety of pro-angiogenic cytokines of which the best characterized is vascular endothelial growth factor (VEGF). Indeed, the first FDA approved anti-angiogenic drug for the treatment of cancer is Avastin, a neutralizing antibody directed against VEGF. This review focuses on cytokines which have been reported to induce tumor angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cytokines / physiology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / physiology
  • Neoplasms / blood supply*
  • Neovascularization, Pathologic / etiology*
  • Vascular Endothelial Growth Factors / physiology*


  • Cytokines
  • Intercellular Signaling Peptides and Proteins
  • Vascular Endothelial Growth Factors