Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood

Early Hum Dev. 2007 Jul;83(7):451-8. doi: 10.1016/j.earlhumdev.2006.08.006. Epub 2006 Sep 26.


Background: Experimental animal data link prenatal stress with sleep disturbance in offspring, but the link in humans is unclear.

Aims: To investigate the link between prenatal maternal anxiety and depression and infant sleep disturbance from 6 to 30 months of age.

Study design: Longitudinal prospective study of a large birth cohort from pregnancy to 30 months. Questionnaire measures of anxiety and depression were completed by mothers at 18 and 32 weeks gestation and at 8 weeks and 8 months postpartum.

Subjects: The ALSPAC cohort, a prospective community study of women in the UK who have been followed since pregnancy.

Outcome measures: Measures of total sleep time, number of awakenings, and broadly defined sleep problems were available on children at ages 6, 18, and 30 months.

Results: Reliable measures of total sleep time, nighttime awakenings, and sleep problems were identified at 6, 18, and 30 months. Higher levels of prenatal maternal anxiety and depression predicted more sleep problems at 18 and 30 months, after controlling for postnatal mood and obstetric and psychosocial covariates; the association was not restricted to clinical extremes. No link with total sleep time was observed.

Conclusions: Mood disturbance in pregnancy has persisting effects on sleep problems in the child, a finding that is consistent with experimental animal research. The findings add to a growing literature showing that maternal prenatal stress, anxiety, and depression may have lasting effects on child development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affective Symptoms / etiology*
  • Child Behavior Disorders
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant Behavior*
  • Infant, Newborn
  • Male
  • Mood Disorders / complications*
  • Parent-Child Relations
  • Pregnancy
  • Pregnancy Complications*
  • Prenatal Exposure Delayed Effects*
  • Prospective Studies
  • Sleep Wake Disorders / etiology*
  • Surveys and Questionnaires