Comparison Between Molecular Epidemiology, Geographical Regions and Drug Resistance in Mycobacterium Tuberculosis Strains Isolated From Iranian and Afghan Patients

Chemotherapy. 2006;52(6):316-20. doi: 10.1159/000095971. Epub 2006 Sep 27.

Abstract

The aim of this study was to determine the prevalence of drug-resistant tuberculosis (TB) and its associated risk factors. The susceptibilities of Mycobacterium tuberculosis isolates were tested against four first-line antituberculous drugs and were typed by spoligotyping. Spoligotyping of M. tuberculosis strains resulted in 95 different patterns that were divided into three evolutionary groups (1-3). Eighty-six (90%) of the isolates had unique patterns that were reported for the first time. Interestingly, 9.4% of the strains belonged to the Beijing family. Multidrug resistance (MDR) was seen in group 1 of the evolutionary scenario. All M. tuberculosis isolates belonging to the Beijing family were associated with a resistance pattern. MDR was much higher in bacteria isolated from Afghan TB patients residing in Iran.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Afghanistan / epidemiology
  • Anti-Bacterial Agents / therapeutic use
  • Antibiotics, Antitubercular / therapeutic use
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Ethambutol / therapeutic use
  • Genotype
  • Humans
  • Iran / epidemiology
  • Isoniazid / therapeutic use
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Epidemiology
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Prevalence
  • Rifampin / therapeutic use
  • Risk Factors
  • Streptomycin / therapeutic use
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Tuberculosis, Multidrug-Resistant / epidemiology*
  • Tuberculosis, Multidrug-Resistant / genetics
  • Tuberculosis, Multidrug-Resistant / microbiology

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antitubercular
  • Ethambutol
  • Isoniazid
  • Rifampin
  • Streptomycin