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Review
. 2006 Dec;1758(12):2096-103.
doi: 10.1016/j.bbamem.2006.08.012. Epub 2006 Aug 26.

Glycosphingolipids and Drug Resistance

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Free article
Review

Glycosphingolipids and Drug Resistance

Valerie Gouaze-Andersson et al. Biochim Biophys Acta. .
Free article

Abstract

Drug resistance, an all too frequent characteristic of cancer, represents a serious barrier to successful treatment. Although many resistance mechanisms have been described, those that involve membrane-resident proteins belonging to the ABC (ATP binding cassette) transporter superfamily are of particular interest. In addition to cancer, the ABC transporter proteins are active in diseases such as malaria and leishmaniasis. A recent renaissance in lipid metabolism, specifically ceramide and sphingolipids, has fueled research and provided insight into the role of glycosphingolipids in multidrug resistance. This article reviews current knowledge on ceramide, glucosylceramide synthase and cerebrosides, and the relationship of these lipids to cellular response to anticancer agents.

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