Effect of lens epithelial cell aspiration on postoperative capsulorhexis contraction with the use of the AcrySof intraocular lens: randomized clinical trial

J Cataract Refract Surg. 2006 Oct;32(10):1621-6. doi: 10.1016/j.jcrs.2006.04.035.


Purpose: To determine whether aspiration of lens epithelial cells (LECs) from under the anterior capsule reduces postoperative contraction of the capsulorhexis aperture.

Setting: Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, United Kingdom.

Methods: This prospective randomized observer-masked study comprised 100 patients who had routine phacoemulsification by the same surgeon at a district general hospital in the United Kingdom. The postoperative changes in capsulorhexis apertures and anterior capsule opacification (ACO) between Group A (aspiration of LECs) and Group B (control) were compared. Digital retroillumination images of the capsulorhexis aperture were taken 1 week and 3 months postoperatively. The area of capsulorhexis aperture was determined with computer software, and capsule opacification was graded subjectively.

Results: Three months postoperatively, the mean decrease in capsulorhexis aperture was 1.9% in Group A and 5.6% in Group B (P = .02). The ACO at 3 months was grade 2 in 44% of eyes in Group A and in 61% in Group B (P = .13).

Conclusion: Aspiration of LECs from the anterior capsule was a safe procedure that reduced capsulorhexis aperture contraction 3 months after cataract surgery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acrylic Resins*
  • Aged
  • Capsulorhexis*
  • Contracture / prevention & control*
  • Epithelial Cells / pathology*
  • Female
  • Humans
  • Lens Capsule, Crystalline / pathology*
  • Lenses, Intraocular*
  • Male
  • Phacoemulsification / methods
  • Postoperative Complications / prevention & control*
  • Suction / methods*


  • Acrylic Resins