Strategies for developing vaccines against H5N1 influenza A viruses

Taisuke Horimoto; Yoshihiro Kawaoka

doi:10.1016/j.molmed.2006.09.003

Strategies for developing vaccines against H5N1 influenza A viruses

Trends Mol Med. 2006 Nov;12(11):506-14. doi: 10.1016/j.molmed.2006.09.003. Epub 2006 Sep 29.

Authors

Taisuke Horimoto¹, Yoshihiro Kawaoka

Affiliation

¹ Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

PMID: 17011235
DOI: 10.1016/j.molmed.2006.09.003

Abstract

Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 subtype) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse-genetics-based inactivated vaccines have been prepared according to World Health Organization (WHO) recommendations and are now undergoing clinical evaluation in several countries. Here, we review the current strategies for the development of H5N1 influenza vaccines, and future directions for vaccine development.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chemistry, Pharmaceutical / methods*
Chickens
Chlorocebus aethiops
Disease Outbreaks / prevention & control*
Humans
Influenza A Virus, H5N1 Subtype / immunology*
Influenza A Virus, H5N1 Subtype / physiology
Influenza Vaccines / genetics*
Influenza Vaccines / immunology*
Influenza in Birds / transmission
Influenza in Birds / virology
Influenza, Human / epidemiology
Influenza, Human / immunology
Influenza, Human / prevention & control*
Models, Genetic
Models, Immunological
Orthomyxoviridae Infections / epidemiology
Vero Cells
Virulence Factors / isolation & purification
Virus Replication

Substances

Influenza Vaccines
Virulence Factors