Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults

J Pediatr. 2006 Oct;149(4):532-6. doi: 10.1016/j.jpeds.2006.05.026.


Objective: To evaluate the adult reproductive outcome in girls with early puberty who participated in a previous random study.

Study design: A total of 22 subjects treated with triptorelin 3.75 mg every 4 weeks (group 1), 18 subjects not treated (group 2), and 22 age-matched normal volunteers (control group) underwent a physical examination, serum hormone level determination, and pelvic ultrasonography.

Results: The characteristics of menstrual cycles, serum hormone levels, and ultrasound results did not differ significantly among the 3 groups examined. The mean ovarian volume and the uterine volume tended to increase in the subjects of group 2, but the differences were not significant. The percentage of subjects who reported being sexually active at the time of the examination was greater in the 2 groups with previous early puberty than in the controls (76% of cases in group 1, 72% in group 2, and 59% in the control group).

Conclusions: Neither early puberty nor its treatment seems to significantly affect the normal adult function of the pituitary-gonadal axis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Luteolytic Agents / therapeutic use*
  • Puberty, Precocious / drug therapy*
  • Reproduction*
  • Time Factors
  • Triptorelin Pamoate / therapeutic use*


  • Luteolytic Agents
  • Triptorelin Pamoate