mTORC2 Caught in a SINful Akt

Dev Cell. 2006 Oct;11(4):433-4. doi: 10.1016/j.devcel.2006.09.005.


The target of rapamycin (TOR), a central controller of cell growth, is found in two distinct, highly conserved multiprotein complexes. Three recent papers in Cell (Jacinto et al., 2006), Developmental Cell (shiota et al., 2006; this issue), and Current Biology (Frias et al., 2006) shed light on mTOR complex 2 (mTORC2) composition and in vivo function. An important new finding is that mTORC2 determines Akt/PKB substrate specificity rather than absolute activity.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Adenosine Triphosphatases / metabolism
  • Animals
  • Fungal Proteins / metabolism
  • Humans
  • Protein Kinases / analysis
  • Protein Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Saccharomyces cerevisiae Proteins
  • Substrate Specificity
  • TOR Serine-Threonine Kinases


  • Adaptor Proteins, Signal Transducing
  • Fungal Proteins
  • MAPKAP1 protein, human
  • SAP1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Adenosine Triphosphatases