Regulation of ribosome biogenesis: where is TOR?

Cell Metab. 2006 Oct;4(4):259-60. doi: 10.1016/j.cmet.2006.09.002.


Li et al., (2006) have shown that TOR complex 1 in yeast binds directly to the rDNA promoter and thereby activates Pol I-dependent synthesis of 35S RNA. This is an important advance in the understanding of how ribosome biogenesis is regulated in response to environmental conditions.

Publication types

  • Review

MeSH terms

  • DNA, Ribosomal / genetics
  • DNA-Directed RNA Polymerases / metabolism
  • Gene Expression Regulation, Fungal
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • RNA / biosynthesis*
  • Ribosomes / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism*


  • DNA, Ribosomal
  • Saccharomyces cerevisiae Proteins
  • RNA
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • TOR1 protein, S cerevisiae
  • DNA-Directed RNA Polymerases