Critical appraisal of the current practice in murine TNBS-induced colitis

Inflamm Bowel Dis. 2006 Oct;12(10):995-9. doi: 10.1097/01.mib.0000227817.54969.5e.


There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendations for the future use of the model.

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Animals
  • Colitis / chemically induced*
  • Disease Models, Animal*
  • Drug Hypersensitivity
  • Gene Expression Profiling / methods
  • Health Planning Guidelines
  • Humans
  • Hypersensitivity, Delayed / chemically induced
  • Mice*
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Trinitrobenzenesulfonic Acid


  • Trinitrobenzenesulfonic Acid