Stretch-activated cation channels with large unitary conductance in leech central neurons

Brain Res. 1990 Aug 20;525(2):322-6. doi: 10.1016/0006-8993(90)90883-d.


Stretch-activated cation channels were identified in the soma membrane of leech central neurons. These channels were almost silent under normal experimental conditions and were distinctly activated by application of negative pressure to the patch pipette. The channels exhibited a preferential selectivity for K+ and a slope conductance of about 200 pS, in symmetrical K+ solution. In cell-attached patches these cation channels were activated by cell swelling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Membrane / physiology
  • Hypotonic Solutions
  • Ion Channels / physiology*
  • Leeches
  • Membrane Potentials / drug effects
  • Neurons / physiology*
  • Potassium / pharmacology
  • Pressure
  • Sodium / pharmacology


  • Hypotonic Solutions
  • Ion Channels
  • Sodium
  • Potassium