Combining non-depolarizing neuromuscular blocking agents: synergism, addition or antagonism?

Curr Opin Anaesthesiol. 1999 Jul;12(4):467-71. doi: 10.1097/00001503-199908000-00013.


As the quality of currently available relaxants has improved, the need to combine relaxants to minimize the incidence and severity of their side-effects has decreased. Little work has been done in the past year characterizing the effects of combining different non-depolarizing neuromuscular blocking agents. That which has been done sheds some light on the nature of their interactions.