Glycan microarray technologies: tools to survey host specificity of influenza viruses

Nat Rev Microbiol. 2006 Nov;4(11):857-64. doi: 10.1038/nrmicro1530. Epub 2006 Oct 2.


New technologies are urgently required for rapid surveillance of the current H5N1 avian influenza A outbreaks to gauge the potential for adaptation of the virus to the human population, a crucial step in the emergence of pandemic influenza virus strains. Owing to the species-specific nature of the interaction between the virus and host glycans, attention has recently focused on novel glycan array technologies that can rapidly assess virus receptor specificity and the potential emergence of human-adapted H5N1 viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Birds
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Disease Outbreaks / veterinary
  • Hemagglutinin Glycoproteins, Influenza Virus / chemistry*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Humans
  • Influenza A Virus, H5N1 Subtype / metabolism*
  • Influenza in Birds / virology
  • Microarray Analysis / instrumentation
  • Microarray Analysis / methods*
  • Microarray Analysis / veterinary
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism*
  • Receptors, Virus / chemistry*
  • Receptors, Virus / metabolism*
  • Species Specificity


  • Hemagglutinin Glycoproteins, Influenza Virus
  • Polysaccharides
  • Receptors, Virus