An Asian patient with intraocular lymphoma treated by intravitreal methotrexate

Jpn J Ophthalmol. 2006 Sep-Oct;50(5):474-478. doi: 10.1007/s10384-005-0327-4.


Background: To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.

Case: A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.

Observations: The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.

Conclusion: Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Biopsy
  • Diagnosis, Differential
  • Eye Neoplasms / diagnosis
  • Eye Neoplasms / drug therapy*
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Injections
  • Lymphoma, B-Cell / diagnosis
  • Lymphoma, B-Cell / drug therapy*
  • Male
  • Methotrexate / administration & dosage*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Taiwan
  • Vitreous Body


  • Antimetabolites, Antineoplastic
  • Methotrexate