Inhibition of ovarian cancer growth and implantation by paclitaxel after laparoscopic surgery in a mouse model

Am J Obstet Gynecol. 2006 Nov;195(5):1278-81. doi: 10.1016/j.ajog.2006.07.035. Epub 2006 Oct 2.

Abstract

Objective: We used an established experimental model to evaluate the influence of intraperitoneal chemotherapy on the generation of laparoscopy-associated metastases and the effectiveness of chemotherapy.

Study design: Twenty-four nude mice underwent laparoscopy with carbon dioxide insufflation and the instillation of a tumor cell suspension with or without paclitaxel into the peritoneal cavity. Mice were allocated to 1 of the following groups (8 mice to each group): (1) controls; (2) paclitaxel given during the operation; (3) paclitaxel given after the operation. Mice were killed 30 days after the procedure, and the peritoneal cavity and port sites were examined for the presence of tumors.

Results: Tumor implantation and port-site metastases were reduced more by the intraoperative intraperitoneal administration of paclitaxel during the operation than by administration after the operation.

Conclusion: Intraoperative intraperitoneal administration of paclitaxel may decrease significantly the occurrence of port-site metastasis and intraperitoneal dissemination in an animal study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / surgery*
  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Drug Administration Schedule
  • Female
  • Humans
  • Injections, Intraperitoneal
  • Intraoperative Period
  • Laparoscopy / adverse effects*
  • Mice
  • Mice, Nude
  • Neoplasm Seeding
  • Neoplasm Transplantation
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / secondary*
  • Paclitaxel / administration & dosage
  • Paclitaxel / pharmacology*
  • Postoperative Period

Substances

  • Antineoplastic Agents, Phytogenic
  • Paclitaxel