Effects of Type II diabetes on muscle microvascular oxygen pressures

Respir Physiol Neurobiol. 2007 May 14;156(2):187-95. doi: 10.1016/j.resp.2006.08.008. Epub 2006 Aug 26.


We tested the hypothesis that muscle microvascular O2 pressure (PmvO2; reflecting the O2 delivery (QO2) to O2 uptake (VO2) ratio) would be lowered in the spinotrapezius muscle of Goto-Kakizaki (GK) Type II diabetic rats (n=7) at rest and during twitch contractions when compared to control (CON; n=5) rats. At rest, PmvO2 was lower in GK versus CON rats (CON: 29+/-2; GK: 18+/-2Torr; P<0.05). At the onset of contractions, GK rats evidenced a faster change in PmvO2 than CON (i.e., time constant (tau); CON: 16+/-4; GK: 6+/-2s; P<0.05). In contrast to the monoexponential fall in PmvO2 to the steady-state level seen in CON, GK rats exhibited a biphasic PmvO2 response that included a blunted (or non-existent) PmvO2 decrease followed by recovery to a steady-state PmvO2 that was at, or slightly above, resting values. Compared with CON, this decreased PmvO2 across the transition to a higher metabolic rate in Type II diabetes would be expected to impair blood-muscle O2 exchange and contractile function.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Analysis of Variance
  • Animals
  • Capillaries / metabolism
  • Diabetes Mellitus, Type 2 / blood*
  • Disease Models, Animal
  • Glucose Intolerance / blood*
  • Male
  • Models, Biological
  • Muscle Contraction / physiology
  • Muscle, Skeletal / blood supply
  • Muscle, Skeletal / metabolism*
  • Oxygen / blood*
  • Oxygen Consumption / physiology
  • Physical Conditioning, Animal / physiology*
  • Rats
  • Rats, Inbred Strains
  • Rats, Wistar
  • Statistics, Nonparametric


  • Oxygen