Presentation, patterns of myocardial damage, and clinical course of viral myocarditis

Circulation. 2006 Oct 10;114(15):1581-90. doi: 10.1161/CIRCULATIONAHA.105.606509. Epub 2006 Oct 2.


Background: Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples.

Methods and results: Consequently, our aim was to evaluate the prevalence and clinical presentation of cardiac PVB19 and/or HHV6 infection in a cohort of myocarditis patients and to follow its clinical course. In addition, we sought to demonstrate patterns of myocardial damage and to determine predictors for chronic heart failure. Our study design consisted of a cardiovascular magnetic resonance protocol as well as endomyocardial biopsies in the myocardial region affected as indicated by cardiovascular magnetic resonance. One hundred twenty-eight patients were enrolled by clinical criteria. In the group of myocarditis patients (n=87), PVB19 (n=49), HHV6 (n=16), and combined PVB19/HHV6 infections (n=15) were detected most frequently. The remaining patients were diagnosed with healing myocarditis (n=15) or did not have myocarditis (n=26). Patients with PVB19 presented in a manner similar to that of myocardial infarction; most had typical subepicardial late gadolinium enhancement in the lateral wall and recovered within months. Conversely, patients with HHV6 and especially with HHV6/PVB19 myocarditis presented with new onset of heart failure, had septal late gadolinium enhancement, and frequently progressed toward chronic heart failure.

Conclusions: Our data indicate that PVB19 and HHV6 are the most important causes for viral myocarditis in Germany and that the clinical presentation is related to the type of virus. Furthermore, clinical presentation, type of virus, and pattern of myocardial damage are related to the clinical course.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biopsy
  • Cardiomyopathy, Dilated / etiology
  • Cardiomyopathy, Dilated / physiopathology
  • Cardiomyopathy, Dilated / virology
  • Cohort Studies
  • Disease Progression
  • Female
  • Germany
  • Heart / virology
  • Heart Ventricles / pathology
  • Herpesvirus 6, Human / pathogenicity
  • Humans
  • Male
  • Middle Aged
  • Myocarditis / complications
  • Myocarditis / epidemiology
  • Myocarditis / physiopathology*
  • Myocarditis / virology*
  • Myocardium / pathology*
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / pathology
  • Parvoviridae Infections / physiopathology
  • Parvovirus B19, Human / pathogenicity
  • Prevalence
  • Roseolovirus Infections / complications*
  • Roseolovirus Infections / pathology
  • Roseolovirus Infections / physiopathology