Effects of astaxanthin supplementation on exercise-induced fatigue in mice

Biol Pharm Bull. 2006 Oct;29(10):2106-10. doi: 10.1248/bpb.29.2106.


The present study was designed to determine the effect of astaxanthin on endurance capacity in male mice aged 4 weeks. Mice were given orally either vehicle or astaxanthin (1.2, 6, or 30 mg/kg body weight) by stomach intubation for 5 weeks. The astaxanthin group showed a significant increase in swimming time to exhaustion as compared to the control group. Blood lactate concentration in the astaxanthin groups was significantly lower than in the control group. In the control group, plasma non-esterfied fatty acid (NEFA) and plasma glucose were decreased by swimming exercise, but in the astaxanthin group, NEFA and plasma glucose were significantly higher than in the control group. Astaxanthin treatment also significantly decreased fat accumulation. These results suggest that improvement in swimming endurance by the administration of astaxanthin is caused by an increase in utilization of fatty acids as an energy source.

MeSH terms

  • Adipose Tissue / drug effects
  • Animals
  • Blood Glucose / analysis
  • Creatine Kinase / blood
  • Fatty Acids, Nonesterified / blood
  • Lactic Acid / blood
  • Liver Glycogen / analysis
  • Male
  • Mice
  • Physical Conditioning, Animal
  • Physical Endurance / drug effects*
  • Reactive Oxygen Species / metabolism
  • Swimming
  • Xanthophylls / pharmacology


  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Liver Glycogen
  • Reactive Oxygen Species
  • Xanthophylls
  • Lactic Acid
  • astaxanthine
  • Creatine Kinase