The discovery of dopamine deficiency in the parkinsonian brain

J Neural Transm Suppl. 2006;(70):9-15. doi: 10.1007/978-3-211-45295-0_3.


This article gives a short historical account of the events and circumstances that led to the discovery of the occurrence of dopamine (DA) in the brain and its deficiency in Parkinson's disease (PD). Some important consequences, for both the basic science and the patient, of the work on DA in the PD brain are also highlighted.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Antiparkinson Agents / history
  • Antiparkinson Agents / therapeutic use
  • Brain Chemistry / physiology*
  • Dopamine / deficiency*
  • History, 20th Century
  • Humans
  • Levodopa / history
  • Levodopa / therapeutic use
  • Neostriatum / metabolism
  • Parkinson Disease / history*
  • Parkinson Disease / metabolism*


  • Antiparkinson Agents
  • Levodopa
  • Dopamine