Cargo takes control of endocytosis

Cell. 2006 Oct 6;127(1):35-7. doi: 10.1016/j.cell.2006.09.012.


Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.

Publication types

  • Comment

MeSH terms

  • Actins / metabolism
  • Animals
  • Clathrin / metabolism*
  • Endocytosis / physiology*
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Transport Vesicles* / chemistry
  • Transport Vesicles* / metabolism


  • Actins
  • Clathrin
  • Microtubule-Associated Proteins
  • Receptors, G-Protein-Coupled