Dendritic protein synthesis, synaptic plasticity, and memory

Cell. 2006 Oct 6;127(1):49-58. doi: 10.1016/j.cell.2006.09.014.


Considerable evidence suggests that the formation of long-term memories requires a critical period of new protein synthesis. Recently, the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction. Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area.

Publication types

  • Review

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Dendrites / ultrastructure
  • Learning / physiology
  • Memory / physiology*
  • Neuronal Plasticity / physiology*
  • Protein Biosynthesis / physiology*
  • Proteome
  • RNA, Messenger / metabolism
  • Synapses / physiology*
  • Time Factors


  • Proteome
  • RNA, Messenger