A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

Nature. 1990 Dec 20-27;348(6303):699-704. doi: 10.1038/348699a0.

Abstract

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / genetics*
  • Cloning, Molecular
  • DNA / genetics
  • Embryo, Mammalian / metabolism
  • Extracellular Matrix / enzymology
  • Female
  • Fibroblasts / metabolism
  • Gene Expression
  • Growth Substances / pharmacology
  • Humans
  • Matrix Metalloproteinase 11
  • Metalloendopeptidases / genetics*
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • RNA / analysis
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Growth Substances
  • RNA
  • DNA
  • Matrix Metalloproteinase 11
  • Metalloendopeptidases
  • Tetradecanoylphorbol Acetate

Associated data

  • GENBANK/X57766