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. 2006 Oct 3;2006(355):pe40.
doi: 10.1126/stke.3552006pe40.

Gene Control by Large Noncoding RNAs


Gene Control by Large Noncoding RNAs

Ilya Shamovsky et al. Sci STKE. .


Large noncoding RNAs (lncRNAs) have emerged as key players in regulating various fundamental cellular processes. Recent reports identify a functional lncRNA, Evf-2, that operates during development to control the expression of specific homeodomain proteins, and they provide important insights into the mechanism of cooperation between a newly discovered nuclear receptor co-repressor protein (SLIRP) and steroid receptor activator RNA. Evf-2 is the first example of lncRNA directly involved in organogenesis in vertebrates.

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