[The revived interest in aldosterone antagonists]

Rev Med Suisse. 2006 Sep 13;2(78):2055-8.
[Article in French]


Aldosterone plays a pivotal role in sodium and water homeostasis, in particular in patients with heart failure or high blood pressure. These medications, when used on top of a standard therapy, improve the outcome of patients with heart failure and are also effective in lowering blood pressure of hypertensive patients. The major risk associated with the use of these antagonists is hyperkalemia, which can be prevented in avoiding their prescription in patients with impaired renal function. Eplerenone has the advantage, compared with spironolactone, to be better tolerated in terms of "hormonal" adverse effects.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects*
  • Drug Therapy, Combination
  • Eplerenone
  • Heart Failure / drug therapy*
  • Heart Failure / physiopathology
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Hypokalemia / chemically induced
  • Mineralocorticoid Receptor Antagonists / adverse effects
  • Mineralocorticoid Receptor Antagonists / pharmacology
  • Mineralocorticoid Receptor Antagonists / therapeutic use*
  • Spironolactone / analogs & derivatives
  • Spironolactone / therapeutic use
  • Treatment Outcome


  • Antihypertensive Agents
  • Mineralocorticoid Receptor Antagonists
  • Spironolactone
  • Eplerenone