Exogenous endoscopy-related infections, pseudo-infections, and toxic reactions: clinical and economic burden

Curr Med Res Opin. 2006 Oct;22(10):2007-21. doi: 10.1185/030079906X121048.


Objectives: The objective of this study was to analyze the characteristics and costs of exogenous endoscopy-related infections, pseudo-infections, and toxic reactions in the US.

Methods: A systematic review of the scientific literature published between 1966 and 2005 was conducted in Medline. Data collection was based on a prospective protocol developed by the authors.

Results: The literature review included 70 outbreaks described in 64 scientific articles. Bronchoscopy accounted for half of all reported outbreaks. Inadequate decontamination practices were the leading cause of contamination; equipment malfunction became the second leading cause of contamination during the period 1990-2004. More than 91% of the infections identified could be prevented by health care providers if quality control systems are improved and implemented. The available economic information concerning exogenous endoscope related events is very limited. A model for the analysis of the economic burden of exogenous endoscopy-related events is proposed.

Conclusions: Proper decontamination practices, the use of protective sheaths, and the improvement of surveillance systems could reduce the clinical and economic burdens associated with exogenous endoscopy-related events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Cross Infection / economics*
  • Cross Infection / epidemiology
  • Cross Infection / etiology*
  • Endoscopy / adverse effects*
  • Endoscopy / economics*
  • Equipment Contamination
  • Humans
  • Infection Control
  • Infections / economics*
  • Infections / epidemiology
  • Infections / etiology*
  • Sepsis / economics
  • Sepsis / epidemiology
  • Sepsis / etiology
  • United States