Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin

Behav Brain Res. 2006 Dec 15;175(2):305-14. doi: 10.1016/j.bbr.2006.08.036. Epub 2006 Oct 4.


Previous exposure to amphetamine attenuates its ability to induce conditioned taste aversion (CTA). Because amphetamine, unlike emetic agents like LiCl, possesses appetitive properties that sensitize when it is administered repeatedly, the present study assessed the contribution of sensitization to this US-pre-exposure effect (US-PEE). It was found that not all sensitizing regimens of systemic amphetamine injections produce a US-PEE. In addition, previous exposure to amphetamine in the VTA, where it acts to induce sensitization but not CTA, did not produce a US-PEE. It is concluded that amphetamine sensitization alone does not modulate this drug's ability to produce CTA. Implications of these findings for anatomically based associative and non-associative models of CTA and the US-PEE are discussed.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Appetitive Behavior / drug effects
  • Association Learning / drug effects*
  • Association Learning / physiology
  • Avoidance Learning / drug effects*
  • Avoidance Learning / physiology
  • Behavior, Animal / drug effects*
  • Central Nervous System Stimulants / pharmacology*
  • Drug Administration Schedule
  • Male
  • Microinjections
  • Motivation
  • Rats
  • Rats, Sprague-Dawley
  • Saccharin
  • Taste / drug effects
  • Taste / physiology
  • Time Factors
  • Ventral Tegmental Area / drug effects*
  • Ventral Tegmental Area / physiology


  • Central Nervous System Stimulants
  • Amphetamine
  • Saccharin