Healthy immune response to allergens: T regulatory cells and more

Curr Opin Immunol. 2006 Dec;18(6):738-44. doi: 10.1016/j.coi.2006.06.003. Epub 2006 Oct 4.


The specific immune response to allergens is decisive in the development of clinically healthy or allergic states. In healthy individuals, the B-cell response varies between there being no response and the production of IgG(4)- or IgG(1)-dominating allergen-specific antibodies in the presence or absence of low amounts of IgE. If a detectable immune response is mounted, T regulatory type 1 (Tr1) cells specific for common environmental allergens consistently represent the dominant subset in healthy individuals. Exposure to high doses of allergens leads to a high concentration of specific IgG(4), detectable IgE and a Tr1 type of immune response. Induction of IL-10- and TGF-beta-producing Tr1 cells, IgG(4) isotype blocking antibodies, and suppressed mast cells, basophils and eosinophils represent major components of a relatively normalized immune response after allergen-specific immunotherapy (SIT).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allergens / immunology*
  • Animals
  • B-Lymphocytes / immunology
  • Cytokines / immunology
  • Dendritic Cells / immunology
  • Humans
  • Hypersensitivity / immunology*
  • Immune Tolerance*
  • Immunoglobulin A / immunology
  • Immunoglobulin G / immunology
  • Signal Transduction / immunology*
  • T-Lymphocytes, Regulatory / immunology*


  • Allergens
  • Cytokines
  • Immunoglobulin A
  • Immunoglobulin G