Treatment of benign prostatic hyperplasia with phytosterols

Br J Urol. 1990 Dec;66(6):639-41. doi: 10.1111/j.1464-410x.1990.tb07199.x.


In a randomised, double-blind study, the preparation Curbicin, obtained from pumpkin seeds and dwarf palm plants (Cucurbita pepo L. and Sabal serrulata), was compared with a placebo in the treatment of symptoms caused by prostatic hyperplasia; 53 patients took part in the study, which was carried out over a 3-month period. Urinary flow, micturition time, residual urine, frequency of micturition and a subjective assessment of the effect of treatment were all significantly improved in the treatment group. No untoward side effects were noted.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Phytosterols / therapeutic use*
  • Prostatic Hyperplasia / complications
  • Prostatic Hyperplasia / drug therapy*
  • Urinary Bladder Neck Obstruction / drug therapy
  • Urinary Bladder Neck Obstruction / etiology
  • Urinary Bladder Neck Obstruction / physiopathology
  • Urodynamics / drug effects


  • Phytosterols